Exposure-response data for nonlethal effects are not available. The acute toxicity reported on this page is of the pure chemical ingredient only and may not reflect the acute toxicity of individual pesticide products. Cases have been described of deliberate self-poisoning which has higher mortality than accidental exposure. Usually, poisoning is by ingestion for suicidal purposes, although accidental poisoning is not uncommon. In 2009, it called for India to ban the product because of its extreme toxicity. Fate in Humans and Animals: Monocrotophos is metabolized and excreted rapidly and does not appear to accumulate within the body (171). Monocrotophos is principally used in agriculture, as a relatively cheap pesticide. Organophosphate poisoning is a continued menace associated with high morbidity and mortality in both resource-crunched developing and developed countries. According to the WHO, swallowing 1,200 milligrams - less than a teaspoon - of monocrotophos can be fatal to humans. A 32-year-old man was admitted to a peripheral hospital following assault with a 100-ml bottle of insecticide called Monocrotophos, an organophosphate. The genotoxic and cytotoxic effects of monocrotophos, an organophosphate insecticide, was investi- gated on human lymphocytes cultured in vitro. 2. 11 12 Monocrotophos inhibits acetylcholinesterase (ChE) activity resulting in an excess of 13 acetylcholine at neuronal synapses and myoneural junctions. Symptoms of monocrotophos poisoning are similar to those of other organophosphate compounds. Its cholinesterase inhibiting activity causes nervous system effects. Investigation of monocrotophos toxic effects on human lymphocytes at cytogenetic level B. Kalyan Chakravarthi 1 , Rambabu Naravaneni 2 , G. H. Philip 1 and C. Srinivasulu Redddy 3 Monocrotophos can be absorbed into the human body through multiple pathways, including inhalation, skin contact and ingestion, and is acutely toxic by all routes of exposure. Monocrotophos, an organophosphate, was first registered in Australia in 1968 and has played a useful role in agriculture as a broad spectrum, systemic insecticide and acaricide in crops such as sorghum, sunflowers, tomatoes and tobacco. The first two modes of exposure put Indian farmers at an unusually high risk. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above. Organ Toxicity: Monocrotophos affects the central nervous system by inhibiting cholinesterase, an enzyme essential for normal nerve impulse transmission. and many other countries, however it is still available in India. 9 There are no inhalation toxicity data on monocrotophos in humans and inhalation data in 10 animals are limited to lethality. person. Poisoning due to absorption through intact or damaged skin is rare. Monocrotophos is an organophosphate insecticide. Cases of human poisoning are characterized by muscular weakness, blurred vision, profuse perspiration, confusion, vomiting, pain, and Monocrotophos is not irritating to skin and eyes. Monocrotophos is an organophosphorus pesticide. Fatal poisoning by accidental dermal absorption is rarely reported for monocrotophos. Extremely toxic; probable oral lethal dose to humans 5-50 mg/kg or between 7 drops and 1 teaspoon for a 70 kg (150 lb.) It is a cholinesterase inhibitor and acts on the nervous system. Uses. It is acutely toxic to birds and humans, so it has been banned in the U.S., the E.U. Monocrotophos was proposed for review in 1996 as part of the second group of chemicals Nervous system by inhibiting cholinesterase, an organophosphate insecticide its extreme toxicity than... 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